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In a Super Bowl LIX rematch, the Philadelphia Eagles (-1.5) battle the Kansas City Chiefs in a key matchup with one of the slimmest margins of Week 2. Other tight NFL lines include Patriots vs. Dolphins (-1.5) and Buccaneers vs. Texans (-2.5).
Which team has value to include in Week 2 NFL bets, and which side of the NFL spread should you target?

NFL Week 2 picks and score predictions: Packers top Commanders, Chiefs lose Super Bowl rematch with Eagles

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The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a 33-17 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.​​​

The Detroit Lions will look to turn around their fortunes after losing 27-13 to the NFC North rival Green Bay Packers in the season opener. The Lions can ill-afford to start off 0-2, especially against another division opponent. Detroit quarterback Jared Goff will also look to improve on his Week 1 numbers. In the loss to the Packers, Goff completed 31 of 39 passes for 225 yards and one touchdown with one interception and an 88.6 rating. The latest Week 2 NFL odds list the Lions at -5.5 against the Bears. â€‹â€‹â€‹

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